منابع مشابه
Suppression of Adjuvant Disease in the Rat by Heterologous Antilymphocyte Globulin
The effect of antilymphocyte globulin (ALG) on adjuvant arthritis, an immunologically induced disease in the rat, was studied. ALG was prepared from the serum of rabbits immunized against rat lymphocytes. Adjuvant arthritis was induced in rats by a single intracutaneous injection of Freund's complete adjuvant; after 9 to 12 days, all control rats developed polyarthritis. Administration of antil...
متن کاملThe Use of Heterologous Antilymphocyte Globulin (alg) in Human Renal and Liver Transplantation.
Early in 1967, preliminary reports were made from our institutions (Starzl, Marchioro et al. 1967; Starzl, Porter et a/., 1967) of the first clinical use of heterologous antilymphocyte globulin (ALG). T h ~ s immunosuppressive agent was prepared from the serum of horses that had been immunized against cadaveric lymphoid tissue, especially spleens (Iwasaki et al., 1967). It was added to therapy ...
متن کاملClinical reactions and serologic changes after the administration of heterologous antilymphocyte globulin to human recipients of renal homografts.
Clinical reactions and serologic in all cases, to alpha globulins in 9 cases, and to SuMM*~y changes after intramuscular adgamma globulins in only 1. This h d i n g indicates ministration of horse anti-human lymphocyte that a safer ALG could be made by removing the globulin (ALG) were studied in 53 human retrace quantities of alpha and beta globulins from cipients of renal homografts. The ALG w...
متن کاملUse of antilymphocyte globulin after cadaveric renal transplantation.
Antilymphocyte globulin (A.L.G.) was prepared by injecting fresh frozen splenic cells subcutaneously into horses. The IgG fraction of the serum was concentrated by a batch technique using diethylaminoethanol-Sephadex. Fourteen patients given this material by intramuscular injection after cadaveric renal transplants, in addition to azathioprine and prednisone, had less evidence of rejection comp...
متن کاملCrossreaction of antilymphocyte globulin with human granulocyte colony-forming cells.
Clinical preparations of horse antilymphocyteglobulin (ALG) were found to inhibit human bone marrow granulocyte colony growth. This effect was enhanced by complement and was dose dependent, being almost complete at ALG concentrations of 100 microgram/ml. Inhibition was a property of ALG but not of normal horse globulin. However, short incubation of ALG with bone marrow cells occasionally stimul...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 1968
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejm196809262791309